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Natural and Life Sciences Hosts (2018)

Andreas Reiner - Biology

Biology and Biotechnology

Cellular Neurobiology

Research Area

Optical Control and Probing of Synaptic Signaling Proteins

We use novel, optical approaches to study membrane proteins, in particular to understand how protein complexes assemble and transmit signals across cell membranes.

Our main focus is on glutamate receptor signaling. Glutamate receptors (GluRs) play a key role in the central nervous system, where they pass excitatory signals across synapses and modulate synaptic strength and plasticity.

We combine biochemical methods, spectroscopic techniques, live cell imaging and electrophysiology to gain further insight into GluR function and physiology. As part of our toolset we use chemical photoswitches to manipulate GluRs with light – a method that allows for the precise control of specific receptor complexes with high spatial and temporal precision. At the same time, the engineering of photo-controllable ion channels and GPCRs provides a powerful tool for optogenetic and pharmacological studies.

Candidate Profile

We are looking forward to host a motivated and independently working scientist, who is interested in exploring projects in the areas of cellular signaling, chemical biology, optogenetics or neurophysiology.

Required is an excellent university degree in Biology, Biochemistry, Chemistry, or a related discipline, as well as a very high motivation to engage in interdisciplinary research and the ability to work in a team. Experience in experimental research and very good English skills are mandatory.

Host Site: Link

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Deniz Kus - Mathematics

Mathematics

Algebra and Geometry

Research Area

My research interests are all sort of representation theory and algebraic
combinatorics. I have strong side interests in the interaction between
representation theory, number theory, basic hypergeometric series, geometry
and combinatorics.

Candidate Profile

The candidate should have a master degree in mathematics, favourably in the
field of representation theory or algebraic combinatorics. Knowledge in
algebraic Lie theory would be an additional advantage.

Host Site: Link

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Sen Cheng - Neuroscience

Institute for Neural Computation

Computational Neuroscience

Research Area

My group studies the cognitive and neural mechanisms of episodic memory and spatial navigation. Ongoing projects in the group cover a wide range of approaches: from neural networks to philosophical analyses. The postdoc will study the neural mechanisms underlying spatial navigation and learning in mammals. We are particularly interested in the role of the brain region called hippocampus in these processes. So the focus of the project will be on modeling the neural processes in the hippocampus using biologically plausible neural network models. There will be plenty of opportunities for interdisciplinary collaborations both within the group and with other groups in the Institute for Neural Computation and Institute for Philosophy II.

Candidate Profile

Candidates should have, or be close to completing, a doctoral degree in neuroscience, robotics, computer science, physics, or a related field. Competence in mathematical modeling and excellent programming skills are crucial. Research experience in computational neuroscience and robotics would be a further asset.

Host Site: Link

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Thomas Günther-Pomorski - Chemistry and Biochemistry

Molecular Biochemistry

Research Area

A fundamental feature of eukaryotic cells is their compartmentalization into distinct organelles by biological membranes. Each membrane is composed of thousands of interacting lipids and proteins that are essential to basic processes from photosynthesis to the maintenance of electrochemical gradients across membranes. Many membrane proteins, including pumps and transporters, form multimeric complexes that can vary and adapt to the functional state of the cell. We are interested in revealing organization, functioning and dynamics of membrane pumps and their complexes. To this end, we have developed a variety of biochemical, biophysical and microscopic techniques including the synthesis of specific lipid probes for characterizing membrane properties, protein-membrane interactions and lipid trafficking in fungi, parasites and mammalian cells. Detailed insight into the molecular functioning of membrane pumps will help to understand vital processes at cellular membranes and pave the way for applications within synthetic biology such as personal medicine, sustainable energy production, and molecular bioelectronics.

Candidate Profile

We would like to support candidates who have or will soon complete a doctoral degree in cell biology, molecular biology, biochemistry, biophysics or related areas and are interested to work on lipid transporters. Competence in molecular techniques, protein biochemistry or cell biology are important. A strong expertise in protein purification and reconstitution would be a further asset. Additionally, we are seeking for candidates with a strong expertise in Leishmania parasite cell culture and biology or confocal microscopy techniques. We expect very good English skills, team spirit and the ability of working independently.

Host Site: Link

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Katrin Marcus - Medical Faculty

Medizinisches Proteom-Center

Research Area

The MPC has an excellent infrastructure with all current, state-of-the-art technologies and methods. More we have a well-documented expertise in proteomics with special focus on neuromuscular and neurodegenerative diseases, cancer, autoimmune diseases as well as bioinformatics & biostatistics. We intensively collaborate with national and international institutions and clinics. As one of the leading institutes in the field of proteomics the MPC can provide all necessary techniques for either in-depth or targeted proteome analyses. In order to analyze and identify proteins, the MPC is equipped with state-of-the-art techniques for mass spectrometry combined with methods for multidimensional protein and peptide separation (e.g. MALDI-TOF/TOF-MS, ESI-IT-MS, ESI-Orbitrap-MS, 2D-gel electrophoresis, DIGE, laser microdissection, protein microarrays, bioinformatics, biostatistics etc.), and has developed several high sensitive methods for protein quantitation and analysis of posttranslational modifications. The visiting researcher will get a broad insight in actual proteomics methods with special application in clinical research.

Candidate Profile

Suitable candidates are required to have already achieved their masters/diploma or doctorate in biochemistry, biology, chemistry, medicine, pharmacy and/or bioinformatics (or related areas), and must show great interest in MS-based technologies, protein-chemical methods, clinical proteomics and/or bioinformatics. Preferable are experiences in one or more of the following fields: instrumental analytics, mass spectrometry and proteomics, nanoHPLC, as well as protein-biochemical methodology. Teamwork and English communication skills as well as the ability to work in an interdisciplinary field of research are wanted.

Host Site: Link

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Ralf-Jürgen Dettmar

Physics

Chair of Astronomy

Research Area

The larger science question of the team is related to the evolution of dwarf and later type disk galaxies, in particular aiming at an understanding of the role of the multiphase interstellar medium (ISM) in objects of this kind. Among the main topics the team is working on is the "outflow vs. infall" problem. Another focus is on the importance of magnetic fields and cosmic ray propagation for the physics of the ISM. From the observational perspective this is addressed in a multiwavelength approach covering the energy spectrum from X-rays to the long-wavelength radio regime. We are therefore involved in a number of instrumental projects and surveys: we have been contributing to the CALIFA survey effort in the optical and we are studying nearby galaxies in the radiocontiunuum (with the CHANGES team) or in the 21cm line (with the HALOGAS team).

Candidate Profile

For the full analysis of the above mentioned survey data we would benefit from support and collaboration in theoretical aspects of stellar and gas dynamics with a focus on phenomena on galactic scales. The candidate we are looking for has experince in these fields, either from analytical or numerical work. She/he has a strong background and interest in aspects of galaxy evolution.

Host Site: Link

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