Natural and Life Sciences Hosts (2017)
Gerhard Röhrle - Mathematics
Algebra and Number Theory
This research group investigates J-P. Serre's notion of G-complete reducibility by means of geometric invariant theory, concentrating on the notions of saturation, relative G-complete reducibility, rationality and building theoretic questions.
One question we aim to pursue is to study Serre's notion of saturation in reductive groups G in connection with his notion of G-complete reducibility.
One of the aims is to show that saturation behaves well with respect to complete reducibility in an arbitrary ambient reductive group G, extending on earlier work for the general linear group.
A second aim is to gain a better understanding of the notion of subgroups of G which are relatively G-completely reducible with respect to a proper reductive subgroup H of G - even for general linear groups this is not properly understood.
Thirdly, we aim to extend this notion to the class of pseudo-reductive groups and study questions analogous to the situation for reductive groups.
The candidate should have a solid background in the theory of linear algebraic groups and their representation theory. Knowledge and exposure within Serre's notion of G-complete reducibility is vital.
Host Site: Link
Sen Cheng - Neuroscience
Institute for Neural Computation
My group studies the cognitive and neural mechanisms of episodic memory and spatial navigation. Ongoing projects in the group cover a wide range of approaches: from neural networks to philosophical analyses. The postdoc will study the neural mechanisms underlying spatial navigation and learning in mammals. We are particularly interested in the role of the brain region called hippocampus in these processes. So the focus of the project will be on modeling the neural processes in the hippocampus using biologically plausible neural network models. There will be plenty of opportunities for interdisciplinary collaborations both within the group and with other groups in the Institute for Neural Computation and Institute for Philosophy II.
Candidates should have, or be close to completing, a doctoral degree in neuroscience, robotics, computer science, physics, or a related field. Competence in mathematical modeling and excellent programming skills are crucial. Research experience in computational neuroscience and robotics would be a further asset.
Host Site: Link
Lukas Gooßen - Organic Chemistry
Chemistry and Biochemistry
Evonic Chair of Organic Chemistry
The research in the Gooßen group is devoted to the development of sustainable transition metal-catalyzed reactions as alternatives to waste-intensive multi-step transformations.
Primary research goals are
- inventing new chemical reactions based on mechanistic considerations
- devising concepts for the selective functionalization of C-C and C-H bonds
- enabling the use of alternative substrates that have inherent advantages with regard to the reduction of salt waste, e.g. carboxylic acids, alcohols, amines
- developing reagents and reactions for late stage fluoroalkylations
- implementig new concepts for the valorization of renewables and of CO2
- gaining an in-depth mechanistic understanding of catalytic reactions with a focus on solvent effects.
- love chemistry as much as we do
- want to do exciting and challenging research at a top international level
- are a skillful chemist full of new ideas
- have good knowledge of English
- are not afraid of computers and laboratory automation
- have a solid understanding of organometallic chemistry
- and feel the desire to go beyond the paved paths of synthesis and catalysis
...you might be just the right person for us.
Qualifications: PhD in Chemistry; good grades and publication record proving chemical understanding and creativity
Host Site: Link
Andreas Reiner - Biology
Biology and Biotechnology
Optical Control and Probing of Synaptic Signaling ProteinsWe use novel, optical approaches to study membrane proteins, in particular to understand how protein complexes assemble and transmit signals across cell membranes.Our main focus is on glutamate receptor signaling. Glutamate receptors (GluRs) play a key role in the central nervous system, where they pass excitatory signals across synapses and modulate synaptic strength and plasticity.We combine biochemical methods, spectroscopic techniques, live cell imaging and electrophysiology to gain further insight into GluR function and physiology. As part of our toolset we use chemical photoswitches to manipulate GluRs with light – a method that allows for the precise control of specific receptor complexes with high spatial and temporal precision. At the same time, the engineering of photo-controllable ion channels and GPCRs provides a powerful tool for optogenetic and pharmacological studies.
We are looking forward to host a motivated and independently working scientist, who is interested in exploring projects in the areas of cellular signaling, chemical biology, optogenetics or neurophysiology. Required is an excellent university degree in Biology, Biochemistry, Chemistry, or a related discipline, as well as a very high motivation to engage in interdisciplinary research and the ability to work in a team. Experience in experimental research and very good English skills are mandatory.
Host Site: Link
Patrik Krieger - Medical Faculty
Institute of Physiology
Dept. of Systems Neuroscience
Sensation in humans is often an active process that involves motion, e.g., moving fingers on a textured surface and eye movements. In this dynamic process, motion and sensation are strongly interdependent: internal motor information is needed to interpret external sensory signals and sensory information is used to shape appropriate behavior.
Sensorimotor integration is the process by which the sensory and motor systems communicate and coordinate with each other. Using the rodent whisker system we analyze the neural mechanisms underlying sensorimotor integration. Questions that are studied are, e.g., coding of object location and objects features, such as texture, and in general how tactile information is used for decision-making.
Combining behavioural assays, optogenetics and electrophysiology we aim to give causal explanations of animal behaviour in terms of the activity in the underlying brain circuits.
You are interested in neuroscience and in particular the neural mechanisms underlying sensory processing. We have a multidisciplinary approach to our research and welcome a broad range of candidates with an education in biology, medicine, biological engineering, physics or mathematics.
We offer an international working environment in a lab fully equipped with cutting edge technologies; this includes a state-of-the art multi-electrode array system for in vivo recordings in combination with optogenetics.
Host Site: Link
Katrin Marcus - Medical Faculty
The MPC has an excellent infrastructure with all current, state-of-the-art technologies and methods. More we have a well-documented expertise in proteomics with special focus on neuromuscular and neurodegenerative diseases, cancer, autoimmune diseases as well as bioinformatics & biostatistics. We intensively collaborate with national and international institutions and clinics. As one of the leading institutes in the field of proteomics the MPC can provide all necessary techniques for either in-depth or targeted proteome analyses. In order to analyze and identify proteins, the MPC is equipped with state-of-the-art techniques for mass spectrometry combined with methods for multidimensional protein and peptide separation (e.g. MALDI-TOF/TOF-MS, ESI-IT-MS, ESI-Orbitrap-MS, 2D-gel electrophoresis, DIGE, laser microdissection, protein microarrays, bioinformatics, biostatistics etc.), and has developed several high sensitive methods for protein quantitation and analysis of posttranslational modifications. The visiting researcher will get a broad insight in actual proteomics methods with special application in clinical research.
Suitable candidates are required to have already achieved their masters/diploma or doctorate in biochemistry, biology, chemistry, medicine, pharmacy and/or bioinformatics (or related areas), and must show great interest in MS-based technologies, protein-chemical methods, clinical proteomics and/or bioinformatics. Preferable are experiences in one or more of the following fields: instrumental analytics, mass spectrometry and proteomics, nanoHPLC, as well as protein-biochemical methodology. Teamwork and English communication skills as well as the ability to work in an interdisciplinary field of research are wanted.
Host Site: Link
Thomas Günther-Pomorski - Chemistry and Biochemistry
A fundamental feature of eukaryotic cells is their compartmentalization into distinct organelles by biological membranes. Each membrane is composed of thousands of interacting lipids and proteins that are essential to basic processes from photosynthesis to the maintenance of electrochemical gradients across membranes. Many membrane proteins, including pumps and transporters, form multimeric complexes that can vary and adapt to the functional state of the cell.
We are interested in revealing organization, functioning and dynamics of membrane pumps and their complexes. To this end, we have developed a variety of biochemical, biophysical and microscopic techniques including the synthesis of specific lipid probes for characterizing membrane properties, protein-membrane interactions and lipid trafficking in fungi, parasites and mammalian cells. Detailed insight into the molecular functioning of membrane pumps will help to understand vital processes at cellular membranes and pave the way for applications within synthetic biology such as personal medicine, sustainable energy production, and molecular bioelectronics.
We would like to support candidates who have or will soon complete a doctoral degree in cell biology, molecular biology, biochemistry, biophysics or related areas and are interested to work on lipid transporters. Competence in molecular techniques, protein biochemistry or cell biology are important. A strong expertise in protein purification and reconstitution would be a further asset. Additionally, we are seeking for candidates with a strong expertise in Leishmania parasite cell culture and biology or confocal microscopy techniques. We expect very good English skills, team spirit and the ability of working independently.
Host Site: Link