Small Molecular Antagonists
Prof. Raid Abdel-Jalil
Sultan Qaboos University
Prof. Raphael Stoll
Faculty of Chemistry and Biochemistry
Abdel-Jalil, R. J. is Associate Professor in organic chemistry at the Department of Chemistry at Sultan Qaboos University. He was a postdoctoral research fellow in Crump Institute for Molecular Imaging at UCLA. Abdel-Jalil, R.J. earned his doctoral degree in Organic Chemistry at Tuebingen University, Germany under the auspices of German Academic Exchange Service (DAAD) Fellowship. He obtained a Master of Science degree and a Bachelor of Chemistry degree from the University of Jordan, Jordan. Abdel-Jalil is the authored/co-authored of over 40-refereed scientific articles as of May 2016. His research interests include development of new methods in organic synthesis, synthesis of biological active compounds and chemical modification of stationary phases. Abdel-Jalil has developed several new methods in chiral and achiral synthesis of heterocyclic systems.
Project Summary & Research Plan
Protein-ligand binding is one of the cornerstones in medicinal chemistry to develop lead compounds for many diseases, such as cancer for instance. Elucidating the mechanism(s) of protein-ligand binding is an essential step towards optimising drug formulae and maximising drug potency and efficacy. We envisage to synthesise drug-like molecules for small GTPases and to investigate the nature of the protein-ligand binding sites by biomolecular NMR spectroscopy.
This VIP project consists of two parts:
- We plan to synthesise and structurally elucidate new compounds and their corresponding intermediates.
- We aim to determine the three-dimensional structures and to analyse the dynamics of these biomolecules as well as their interaction with these newly synthesised compounds in solution at near-physiological conditions using multidimensional NMR spectroscopy.
Activities in 2016
Prof. Abdel-Jalil visited RUB in 2016 in July, August, and in January 2017. During the summer term of 2016 he offered a lecture series on applied spectroscopy. Furthermore, he discussed research ideas and projectes with PhD students of the Faculty of Chemistry and Biochemistry. In December 2016, Prof. Abdel-Jalil and Raphael Stoll participated at the PHARMAMED-2016 conference in Dubai, UAE, in order to present their research results.
- Al-Harthy T, Zoghaib WM, Pflüger M, Schöpel M, Önder K, Reitsammer M, Hundsberger H, Stoll R, Abdel-Jalil R. (2016) Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles. Molecules 21(10). pii: E1290..
- Schöpel M., Potheraveedu V.N., Al-Harthy T., Abdel-Jalil R., Heumann R., Stoll R. (2017) The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: Structure and Function. Biological Chemistry, 398:577-588.
- Arnolds O., Zhong X., Yip K.T., Schöpel M., Kohl B., Pütz S., Abdel-Jalil R., Stoll R. (2017) NMR-based drug development and improvement against malignant melanoma - implications for the MIA protein family. Current Medicinal Chemistry, 24:1788-1796.